We have received reports that some users have had difficulty running Homeworld: Deserts of Kharak on a system with a 32-bit operating system. If you are attempting to run the game on a 32-bit system, reducing graphics options may resolve the issue.
If you continue to experience this issue after following the advice above, please submit a support ticket at https://gearboxsoftware.zendesk.com/.
Instability When Running the Game on 32-bit Systems.
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